Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy
نویسندگان
چکیده
منابع مشابه
Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy
Rhenium-188, obtained from an alumina-based tungsten-188/rhenium-188 generator, is actually considered a useful candidate for labeling biomolecules such as antibodies, antibody fragments, peptides, and DNAs for radiotherapy. There is a widespread interest in the availability of labeling procedures that allow obtaining 188Re-labeled radiopharmaceuticals for various therapeutic applications, in p...
متن کاملDirect radiolabeling of monoclonal antibodies with generator-produced rhenium-188 for radioimmunotherapy: labeling and animal biodistribution studies.
The use of 188Re from an alumina-based 188W/188Re generator has been investigated for antibody radiolabeling. It was found that, with simple labeling techniques, 188Re can be used immediately after elution. The direct radiolabeling of intact antibodies with 188Re is described. Lyophilized antibody preparations have been reconstituted with 188Re taken directly from the generator at specific acti...
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UNLABELLED Targeted α-particle radiation using the radioisotope (225)Ac is a promising form of therapy for various types of cancer. Historic obstacles to the use of (225)Ac have been the difficulty in finding suitable chelators to stably attach it to targeting vehicles such as peptides and monoclonal antibodies, the low specific activities of the products, and the lack of cost-effective radiola...
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1Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York; 2Weill Cornell Medical College, New York, New York; 3Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York; 4Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; 5Department of Psychiatry and Behavioral...
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BACKGROUND We previously described a two-antibody model of (64)Cu radioimmunotherapy to evaluate low-dose, solid-tumor response. This model was designed to test the hypothesis that cellular internalization is critical in causing tumor cell death by mechanisms in addition to radiation damage. The purpose of the present study was to estimate radiation dosimetry for both antibodies (mAbs) using po...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2017
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2017/5923609